2. Signaling Pathways
  3. GPCR/G Protein
  4. Adenylate Cyclase

Adenylate Cyclase

Adenylyl cyclase

Adenylate Cyclase

Related Products

PDF 0.35 MB

Adenylyl cyclases (ACs) are enzymes that catalyze the production of cyclic adenosine monophosphate (cAMP) from adenosine triphosphate (ATP). Adenylyl cyclases integrate positive and negative signals that act through G protein-coupled cell-surface receptors with other extracellular stimuli to finely regulate levels of cAMP within the cell. Humans express nine isoforms of membranous ACs and a soluble AC.

Based on regulatory properties, transmembrane ACs are classified into four groups: Group I: Ca2+/calmodulin-stimulated AC1, AC3, AC8; Group II: Gβγ-stimulated and Ca2+-insensitive AC2, AC4, AC7; Group III: Gαi/Ca2+/PKA-inhibited AC5, AC6; Group IV: forskolin/Ca2+/Gβγ-insensitive AC9. The soluble AC, unlike the transmembrane ACs, is insensitive to hormones, G proteins and forskolin, a diterpene extracted from the root of the plant Coleus forskohlii that directly activates all isoforms of transmembrane ACs except AC9.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-122357
    Bestim
    		Inhibitor 98.73%
    Bestim (γ-Glu-Trp) is a dipeptide, which exhibits high affinity to murine peritoneal macrophages, thymocytes, and plasma membranes isolated from these cells, with Kds of 3.1, 2.1, 18.6 and 16.7 nM, respectively. Bestim inhibits adenylate cyclase in the membranes of murine macrophages and thymocytes. Bestim exhibits immunomodulatory efficacy.
    Bestim
  • HY-169263
    AC10142A
    		Inhibitor
    AC10142A is a selective Adenylyl Cyclase Type 1 inhibitor with IC50 of 0.26 μM. AC10142A can be used to study pain models.
    AC10142A
  • HY-P0004R
    Lysipressin (Standard)
    		Activator
    Lysipressin (Standard) is the analytical standard of Lysipressin. This product is intended for research and analytical applications. Lysipressin (Lysine vasopressin) is antidiuretic hormone that have been found in pigs and some marsupial families. Lysipressin induces contraction of the rabbit urinary bladder smooth muscle, activate adenylate-cyclase.
    Lysipressin (Standard)
  • HY-116540
    L 858051
    		Activator
    L 858051 is an analog of Forskolin (HY-15371) that activates adenylate cyclase while also having modulatory effects on intracellular cAMP levels, particularly enhancing the CNG current in cardiac myocytes.
    L 858051
  • HY-131776A
    2-Chloro-ADP sodium
    		Inhibitor
    2-Chloro-ADP (2-Chloroadenosine 5′-diphosphate) sodium is a Adenosine 5'-diphosphate (ADP; HY-W010918) derivative that induces human platelet aggregation and inhibits stimulated adenylate cyclase. 2-Chloro-ADP sodium inhibits mortalin nucleotide-binding domain (NBD) with a Ki of 45.05 μM.
    2-Chloro-ADP sodium
  • HY-171909A
    Glycerophosphoinositol 4-phosphate disodium
    		Inhibitor
    Glycerophosphoinositol 4-phosphate (GroPIns-4-P) disodium is a metabolite of phospholipase A and an inhibitor of adenylylcyclase. Glycerophosphoinositol 4-phosphate disodium can regulate cAMP-dependent cellular functions. Glycerophosphoinositol 4-phosphate disodium can also induce the formation of membrane ruffles and stress fibers in serum-starved Swiss 3T3 cells by activating the small GTPases Rac and Rho, respectively. Glycerophosphoinositol 4-phosphate disodium can be used in research on cancer cell motility and invasiveness.
    Glycerophosphoinositol 4-phosphate disodium
  • HY-P2702
    Helodormin
    		Agonist
    Helodormin is a VIP-secretin-like peptide isolated from the venom of the Mexican monster lizard (Heloderma suspectum). Helodormin affects a variety of cellular functions by modulating intracellular signaling through activation of adenylate cyclase. Helodormin can be used to study the evolution and function of the secretin and VIP peptide families.
    Helodormin
  • HY-137683A
    Guanosine 5'-O-(2-thiodiphosphate) trisodium
    		Inhibitor
    Guanosine 5'-O-(2-thiodiphosphate) (trisodium) (GDPβS (trisodium)) is a non-hydrolyzable derivative of GDP. Guanosine 5'-O-(2-thiodiphosphate) (trisodium) is an inhibitor of adenylyl caclase (AC) (Ki = 600 nM). Guanosine 5'-O-(2-thiodiphosphate) (trisodium) partially activates AC in the absence of GPT in cerebral cortex membranes of rodent models (EC50 = 400 nM). Guanosine 5'-O-(2-thiodiphosphate) (trisodium) prevents the release of norepinephrine-induced nitric oxide in cardiac ventricular myocytes.
    Guanosine 5'-O-(2-thiodiphosphate) trisodium
  • HY-P990425
    Anti-GPR73/PROKR1 Antibody
    		Inhibitor
    Anti-GPR73/PROKR1 Antibody is a CHO-expressed human antibody that targets GPR73/PROKR1. Anti-GPR73/PROKR1 Antibody features a huIgG4SP heavy chain and a huκ light chain, with an expected molecular weight (MW) of 150 kDa. The isotype control for Anti-GPR73/PROKR1 Antibody can be referenced as Human IgG1 kappa, Isotype Control (HY-P99001).
    Anti-GPR73/PROKR1 Antibody
  • HY-101863
    CB-6673567
    		Inhibitor
    CB-6673567 is a selective AC1 inhibitor with an IC50 of 77 μM .CB-6673567blocks the choline-induced cAMP increase and can be used for cardiovascular diseases research.
    CB-6673567
  • HY-P3647
    [DPro10] Dynorphin A (1-11), porcine
    		Inhibitor
    [DPro10] Dynorphin A (1-11), porcine, a N-Alkylated derivative, is a potent κ-opioid receptor agonist with a Ki value of 0.13 nM. [DPro10] Dynorphin A (1-11), porcine has analgesic property.
    [DPro10] Dynorphin A (1-11), porcine
  • HY-122221
    KUM 32
    		Inhibitor
    KUM 32 is a potent antagonist of epinephrine-induced platelet aggregation. KUM 32 is an adenylate cyclase activity inhibitor. KUM 32 binds to the alpha 2 adrenergic receptor of human platelets.
    KUM 32
  • HY-P1158
    [Ala2,8,9,11,19,22,24,25,27,28]-VIP
    [Ala2,8,9,11,19,22,24,25,27,28]-VIP is an analog vasoactive intestinal polypeptide (VIP) with high affinity and selectivity for human VIP/pituitary adenylate cyclase-activating polypeptide 1 (hVPAC1). VIP is a widespread neurotransmitter.
    [Ala2,8,9,11,19,22,24,25,27,28]-VIP
  • HY-122148
    DA 4626
    		Inhibitor
    DA 4626 is a competitive H2-histamine receptor antagonist. DA 4626 inhibits adenylate cyclase activity with a KB value of 40 nM.
    DA 4626
  • HY-128103
    Glucagon receptor antagonist-7
    		Activator
    Glucagon receptor antagonist-7 (Compound 1) is an antagonist for hGCGR, that inhibits the binding of 125I-labeled glucagon to the human glucagon receptor (hGCGR) with IC50 of 181 nM. Glucagon receptor antagonist-7 activates glucagon-stimulated adenylyl cyclase with a KDB of 81 nM in CHO cell. Glucagon receptor antagonist-7 inhibits glucagon-mediated glycogenolysis in human hepatocytes, and lowers blood glucose levels.
    Glucagon receptor antagonist-7
  • HY-P2090
    Angiopeptin
    		Inhibitor
    Angiopeptin, a cyclic octapeptide analogue of somatostatin, is a weak sst2/sst5 receptor partial agonist with IC50 values of 0.26 nM and 6.92 nM, respectively. Angiopeptin is a potent inhibitor of growth hormone release and insulin-like growth factor-1 (IGF-1) production. Angiopeptin inhibits adenylate cyclase or stimulates extracellular acidification. Angiopeptin has the potential for coronary atherosclerosis research.
    Angiopeptin
  • HY-126055
    Hadacidin
    		Inhibitor
    Hadacidin is a competitive inhibitor of adenylate synthase. Hadacidin binds to the active site of adenylate synthase, competitively inhibiting L-aspartate binding. Hadacidin can be used in drug design, to help develop new inhibitors or activators to regulate adenylate synthase activity, and to play a role in the study of related diseases.
    Hadacidin
  • HY-103191
    1,9-Dideoxyforskolin
    		Control
    1,9-Dideoxyforskolin is an inactive analog of forskolin.
    1,9-Dideoxyforskolin
  • HY-130176
    UFP-512
    		Inhibitor
    UFP-512 is a selective and potent σ-opioid receptor (DOP receptor) peptidic agonist with antidepressant- and anxiolytic-like effects. UFP-512 exhibits as a potent agonist on adenylyl cyclase inhibition and Erk1/2 activation. UFP-512 induces phosphorylation of DOP receptors on Ser363 with a low desensitization of the cAMP pathway. UFP-512 is promising for research of mood disorders.
    UFP-512
  • HY-157150
    mAC2-IN-1
    		Inhibitor
    mAC2-IN-1 (compound 14) is a potent and selective human adenylate cyclases (mACs) inhibitor with an IC50 of 4.45 μM. mAC2-IN-1 has low activity on mAC1 and mAC5.
    mAC2-IN-1
Cat. No. Product Name / Synonyms Application Reactivity